Course in: HAEMATO-ONCOLOGY AND CLINICAL-TRANSLATIONAL INTERNAL MEDICINE

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Academic year 2023/2024
Department of Internal Medicine and Medical Specialties
Università di Genova
EQF level: 8
39° cicle
Field of study: health and pharmacy natural sciences, mathematics, physics and statistics
Place of teaching
genova (GE), italy
Attendance methods
Full time
Languages in which the course is held
Italian
University formative credits
180
Cost
528
Scholarships
13 

Course contents

EMATOLOGIA TRASLAZIONALE:
- Overview of main biological features observed in blood cancers: leukemias, lymphomas and multiple myeloma
- Novel therapeutic approaches for the treatment of hematologic malignancies by use of precision-medicine strategies
- The role of single-cell profiling and related technologies for studying tumor heterogeneity
- Bioinformatics approaches used to investigate hematologic malignancies
- The role of bone marrow microenvironment in the pathophysiology of hematologic malignancies

CLINICAL PHATOPHYSIOLOGY OF ENDOCRINE AND METABOLIC DISORDERS
-Pathophysiology of pituitary secretion, in particular the hypothalamic-somatotropinic and prolactinic axis and to the IGF1 system
-Physiopathology of somatostatin receptors in neuroendocrine and pituitary tumors
- Epidemiological and clinical aspects of thyroid cancer
-Cellular mechanisms of action of insulin and other growth factors

CLINICAL PATHOPHYSIOLOGY OF RENAL, CARDIOVASCULAR, ARTERIAL HYPERTENSIVE DISEASES
-Hemodynamic and metabolic mechanisms involved in the development of renal and extra-renal organ damage
- Cardiovascular and renal risk factors in hypertension, diabetic nephropathy, glomerulonephritis and kidney transplantation.
- Atherosclerosis, diabetic nephropathy, chronic kidney disease: role of innate and acquired immune system.
- Biology, pathophysiology and epidemiology of heart failure.
- Clinical experimental cardio-oncology
- Thrombosis and anticoagulation in atrial fibrillation and acute coronary syndromes.
- Role of inflammatory mediators in ischemic heart disease, in ischemic stroke, in metabolic and kidney diseases and their complications.

ONCOLOGIC GENETICS AND MOLECULAR PATHOLOGY
Rare or hereditary cancers molecular determinants of carcinogenesis: identification and functional characterization of genomic variants predictive of susceptibility, prognosis and response to therapy.

GERONTOLOGY, PHATOPHYSIOLOGY OF GERATRIC DISEASES AND ANTI-AGING MEDICINE
-The biochemistry of aging: regulation of i) autophagy, ii) IGF-1 signaling, iii) intracellular NAD , iv) sirtuins, v) response to oxidative stress.
-Physiopathology of frailty in the elderly.
-Aging and tumors: biology, main clinical problems in treatment, geriatric profiling of the elderly affected by cancer.
-Caloric restriction and fasting as strategies for the promotion of longevity and for the treatment of diseases: biological rationale and clinical evidence.
-The personalization of treatment of senior patients in the medical or surgical setting

DISEASES OF THE DIGESTIVE SYSTEM AND OF THE LIVER
- Eosinophilic Esophagitis and innate immunity: evaluation of pathophysiological mechanisms as a guide to potential treatment
- Use of Artificial Intelligence-assisted endoscopy in the diagnosis of precancerous lesions of the colon.
- Rehabilitation of the edentulous patient using prostheses on implants with different loading protocols (research theme for grant funded within D.M. 351/2022)
- Peri-implant tissue diseases and prognostic factors predicting implant success (research theme for grant funded within D.M. 351/2022)
- Peri-implant pathology (research theme for grant funded within D.M. 351/2022)
- The rehabilitation of the atrophic maxilla (research theme for grant funded within D.M. 351/2022)
- Maintenance and follow-up of implant rehabilitation (research theme for grant funded within D.M. 351/2022)

TRANSLATIONAL ONCOLOGY
- Monitoring of solid neoplasms by analysis of circulating nucleic acids.
- Study of the molecular factors that are prognostic and predictive of response in solid neoplasms.
- Preclinical studies of associations between new antineoplastic drugs.
- Pre-clinical and clinical trials in translational oncology.
- Innovative therapeutic approaches in solid tumors and haematological neoplasms.
- Tumor microenvironment and immune response to tumors.
- Study of the molecular and pathogenetic aspects of cardio-toxicity from antiblastic drugs.
- Study of the interactions between tumor cells and the immune system through systems biology approaches.
- Identification of factors that are predictive of response to immunotherapy through immunogenomic approaches
Page of the course on the University's website

Teaching

Place of teaching
genova (GE), italy
University formative credits
180
Attendance methods
Full time
Languages in which the course is held
Italian

Admission requirements

Type of degree required
2nd Level Degree
Foreign language skills
English
Other educational requirements
those who have an equivalent foreign academic qualification

Admission

Available places
15
Admission
Admission selection
Cost
528 €
Scholarships
13
13 grants, annual grant € 16500

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Other editions of the same course
Academic year edition 2022/2023Academic year edition 2021/2022Academic year edition 2020/2021
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